α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress
نویسندگان
چکیده
منابع مشابه
Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression
Mitochondrial ferritin (FtMt) is a type of ferritin that sequesters iron. Previous studies have shown that FtMt is expressed by dopaminergic neurons in the substantia nigra and that it may be involved in the pathology of Parkinson's disease. However, the functional roles of FtMt in dopaminergic neurons remain unclear. In this study, we investigated the function of FtMt in α-synuclein regulation...
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Parkinson’s Disease is a neurodegenerative disease that is pathologically characterized by abnormal α-synuclein protein aggregation, dopamine depletion in nigrostriatal neurons, and the subsequent death of these neurons. Oxidative stress has been widely implicated as a cause for neurodegenerative diseases, especially Parkinson’s Disease (PD). The mechanisms by which oxidative stress occurs in P...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2000
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64553-1